were all established in the regions dominated by the growing
cities of Pittsburgh, Cincinnati, and Louisville
Thus, about the year 1800, the great industries of the young West
were all established in the regions dominated by the growing
cities of Pittsburgh, Cincinnati, and Louisville. But, since the
combined population of these centers could not have been over
three thousand in the year 1800, it is evident that the adjacent
rural population and the people living in every neighboring creek
and river valley were chiefly responsible for the large trade
that already existed between this corner of the Mississippi basin
and the South.